Activated CD27+ and CD27- memory B cells accumulate in the joints of patients with juvenile idiopathic arthritis
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چکیده
منابع مشابه
Activated CD27+ and CD27- memory B cells accumulate in the joints of patients with juvenile idiopathic arthritis
The expression of the costimulatory molecules CD80 and CD86 was increased on synovial fluid CD19+ B cells as compared to peripheral blood. CD80/CD86 expression on these B cells could be shown to induce alloreactive T cell proliferation in vitro. Most of the synovial fluid B cells belonged to the CD27+IgDclass-switched memory B cell subset. However, almost half of the CD27 negative synovial B ce...
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Memory B cells are generated in germinal centers (GC) and contribute to serological immunity by rapidly differentiating into plasma cells. Human memory B cells can be identified by the expression of CD27. These cells exhibit more rapid responses than naive (CD27-) B cells following stimulation in vitro, consistent with the heightened kinetics of secondary responses in vivo. CD27+ B cells expres...
متن کاملThe joints in juvenile idiopathic arthritis
UNLABELLED Juvenile idiopathic arthritis is the most common rheumatic entity in childhood. Imaging has become an important supplement to the clinical assessment of children with JIA. Radiographs still play an important role in the workup, and long-term follow-up in children with JIA, but are not sensitive to findings in the early disease stage. Both ultrasound and MRI are more sensitive to infl...
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Granulomas that occur in sarcoidosis are histologically identical to those found in a subset of Common Variable Immunodeficiency (CVID) patients where they are associated with a reduction in class switched memory B lymphocytes. The aim of this study was to investigate whether the abnormalities in peripheral blood lymphocyte populations associated with granulomatous variant CVID (gvCVID) are als...
متن کاملPhenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis
INTRODUCTION In chronic inflammatory disorders, B cells can contribute to tissue damage by autoantibody production and antigen presentation to T cells. Here, we have characterized synovial fluid and tissue B-cell subsets in patients with oligoarticular juvenile idiopathic arthritis (JIA), an issue not addressed before in detail. METHODS B cells from synovial fluid (SF) and peripheral blood (P...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2008
ISSN: 1546-0096
DOI: 10.1186/1546-0096-6-s1-p19